Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Total Carbohydrate
< 1 g
< 1%**
Echinacea Root (Echinacea purpurea)
800 mg
†
Top Medical Research Studies
9
We explored the potential of Echinacea purpurea polysaccharides (EPP) in combating hepatocellular carcinoma (HCC), a common form of liver cancer. The study showcased how EPP can effectively reduce liver damage associated with HCC, hinder tumor growth, and even encourage cancer cell death.
After treatment with EPP, our observations revealed an increase in beneficial gut bacteria that produce short-chain fatty acids like propionic and butyric acids. This shift in gut microbiota plays a crucial role in strengthening the gut barrier and preventing harmful substances, like lipopolysaccharides (LPS), from leaking into the bloodstream.
Furthermore, the study demonstrated that controlling LPS leakage could inhibit key inflammatory pathways linked to HCC progression. This is significant because reducing inflammation can potentially slow down tumor growth. Overall, our findings suggest that EPP helps regulate the body's systems through gut health, thereby impacting liver cancer outcomes positively.
These insights open up promising avenues for utilizing Echinacea's natural properties in liver disease treatment, particularly in HCC.
After treatment with EPP, our observations revealed an increase in beneficial gut bacteria that produce short-chain fatty acids like propionic and butyric acids. This shift in gut microbiota plays a crucial role in strengthening the gut barrier and preventing harmful substances, like lipopolysaccharides (LPS), from leaking into the bloodstream.
Furthermore, the study demonstrated that controlling LPS leakage could inhibit key inflammatory pathways linked to HCC progression. This is significant because reducing inflammation can potentially slow down tumor growth. Overall, our findings suggest that EPP helps regulate the body's systems through gut health, thereby impacting liver cancer outcomes positively.
These insights open up promising avenues for utilizing Echinacea's natural properties in liver disease treatment, particularly in HCC.
Read More
9
Our exploration focused on how Echinacea purpurea polysaccharide (EPPS) helps protect the liver from damage caused by acetaminophen (APAP) overdose, a leading cause of drug-induced liver injuries. This study observed that EPPS has significant antioxidant properties and may help in regulating the immune system.
We noticed that EPPS reduced inflammation and oxidative stress in liver cells when faced with the harmful effects of APAP. Through various tests, it became clear that EPPS could enhance autophagy—a process that helps the body clear out damaged cells—thereby safeguarding liver health.
Importantly, the research highlighted that the hepatoprotective effects of EPPS are linked to a Parkin-dependent mechanism, indicating a deeper role of autophagy in this protective process. The potential for using EPPS as a therapeutic option for combating acetaminophen-induced liver injury indicates a promising direction for future treatments.
We noticed that EPPS reduced inflammation and oxidative stress in liver cells when faced with the harmful effects of APAP. Through various tests, it became clear that EPPS could enhance autophagy—a process that helps the body clear out damaged cells—thereby safeguarding liver health.
Importantly, the research highlighted that the hepatoprotective effects of EPPS are linked to a Parkin-dependent mechanism, indicating a deeper role of autophagy in this protective process. The potential for using EPPS as a therapeutic option for combating acetaminophen-induced liver injury indicates a promising direction for future treatments.
Read More
9
Echinacea improves liver health
We investigated how Echinacea purpurea polysaccharide (EPP) affects liver disease, particularly in the context of alcoholic liver disease (ALD). Through a combination of microbiome analysis and liver metabolomics, we aimed to understand how EPP impacts gut health and consequently liver metabolism.
Our results revealed that EPP can reverse changes in gut microbiota caused by alcohol consumption. Specifically, we observed an increase in beneficial bacteria such as Muribaculaceae, Lactobacillus, and Bacteroides, while harmful bacteria like Escherichia_Shigella and Enterococcus decreased. This shift in gut flora is critical as it can enhance gut barrier integrity through the production of short-chain fatty acids, particularly n-butyric acid.
Furthermore, EPP improved liver metabolic profiles, with highlighted metabolites and metabolic pathways related to nitrogen metabolism coming to the forefront. Notably, we found significant connections between the gut microbes and liver metabolites, showcasing that EPP helps to alleviate liver damage by working through the gut-liver axis. Overall, our findings shed light on a promising intervention pathway for addressing alcohol-related liver diseases.
Our results revealed that EPP can reverse changes in gut microbiota caused by alcohol consumption. Specifically, we observed an increase in beneficial bacteria such as Muribaculaceae, Lactobacillus, and Bacteroides, while harmful bacteria like Escherichia_Shigella and Enterococcus decreased. This shift in gut flora is critical as it can enhance gut barrier integrity through the production of short-chain fatty acids, particularly n-butyric acid.
Furthermore, EPP improved liver metabolic profiles, with highlighted metabolites and metabolic pathways related to nitrogen metabolism coming to the forefront. Notably, we found significant connections between the gut microbes and liver metabolites, showcasing that EPP helps to alleviate liver damage by working through the gut-liver axis. Overall, our findings shed light on a promising intervention pathway for addressing alcohol-related liver diseases.
Read More
Most Useful Reviews
7.5
Boosts immunity
1 people found this helpful
Echinacea has significantly bolstered my immunity and cleansed my lymphatic system and blood. It combats viruses, bacteria, and fungi, effectively activating my body's defences against illness. I've noticed positive effects on my bronchial and pulmonary health, and it helps with otitis and sinusitis. I take one capsule daily.
Read More
7.5
Supports liver health
This dietary supplement excellently promotes liver health and improves skin. It features a natural and safe formula, offering cumulative benefits without concerns. With easy-to-use packaging, it is suitable for all ages.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8
- All Researches
9
We explored the potential of Echinacea purpurea polysaccharides (EPP) in combating hepatocellular carcinoma (HCC), a common form of liver cancer. The study showcased how EPP can effectively reduce liver damage associated with HCC, hinder tumor growth, and even encourage cancer cell death.
After treatment with EPP, our observations revealed an increase in beneficial gut bacteria that produce short-chain fatty acids like propionic and butyric acids. This shift in gut microbiota plays a crucial role in strengthening the gut barrier and preventing harmful substances, like lipopolysaccharides (LPS), from leaking into the bloodstream.
Furthermore, the study demonstrated that controlling LPS leakage could inhibit key inflammatory pathways linked to HCC progression. This is significant because reducing inflammation can potentially slow down tumor growth. Overall, our findings suggest that EPP helps regulate the body's systems through gut health, thereby impacting liver cancer outcomes positively.
These insights open up promising avenues for utilizing Echinacea's natural properties in liver disease treatment, particularly in HCC.
After treatment with EPP, our observations revealed an increase in beneficial gut bacteria that produce short-chain fatty acids like propionic and butyric acids. This shift in gut microbiota plays a crucial role in strengthening the gut barrier and preventing harmful substances, like lipopolysaccharides (LPS), from leaking into the bloodstream.
Furthermore, the study demonstrated that controlling LPS leakage could inhibit key inflammatory pathways linked to HCC progression. This is significant because reducing inflammation can potentially slow down tumor growth. Overall, our findings suggest that EPP helps regulate the body's systems through gut health, thereby impacting liver cancer outcomes positively.
These insights open up promising avenues for utilizing Echinacea's natural properties in liver disease treatment, particularly in HCC.
Read More
9
Our exploration focused on how Echinacea purpurea polysaccharide (EPPS) helps protect the liver from damage caused by acetaminophen (APAP) overdose, a leading cause of drug-induced liver injuries. This study observed that EPPS has significant antioxidant properties and may help in regulating the immune system.
We noticed that EPPS reduced inflammation and oxidative stress in liver cells when faced with the harmful effects of APAP. Through various tests, it became clear that EPPS could enhance autophagy—a process that helps the body clear out damaged cells—thereby safeguarding liver health.
Importantly, the research highlighted that the hepatoprotective effects of EPPS are linked to a Parkin-dependent mechanism, indicating a deeper role of autophagy in this protective process. The potential for using EPPS as a therapeutic option for combating acetaminophen-induced liver injury indicates a promising direction for future treatments.
We noticed that EPPS reduced inflammation and oxidative stress in liver cells when faced with the harmful effects of APAP. Through various tests, it became clear that EPPS could enhance autophagy—a process that helps the body clear out damaged cells—thereby safeguarding liver health.
Importantly, the research highlighted that the hepatoprotective effects of EPPS are linked to a Parkin-dependent mechanism, indicating a deeper role of autophagy in this protective process. The potential for using EPPS as a therapeutic option for combating acetaminophen-induced liver injury indicates a promising direction for future treatments.
Read More
9
Echinacea improves liver health
We investigated how Echinacea purpurea polysaccharide (EPP) affects liver disease, particularly in the context of alcoholic liver disease (ALD). Through a combination of microbiome analysis and liver metabolomics, we aimed to understand how EPP impacts gut health and consequently liver metabolism.
Our results revealed that EPP can reverse changes in gut microbiota caused by alcohol consumption. Specifically, we observed an increase in beneficial bacteria such as Muribaculaceae, Lactobacillus, and Bacteroides, while harmful bacteria like Escherichia_Shigella and Enterococcus decreased. This shift in gut flora is critical as it can enhance gut barrier integrity through the production of short-chain fatty acids, particularly n-butyric acid.
Furthermore, EPP improved liver metabolic profiles, with highlighted metabolites and metabolic pathways related to nitrogen metabolism coming to the forefront. Notably, we found significant connections between the gut microbes and liver metabolites, showcasing that EPP helps to alleviate liver damage by working through the gut-liver axis. Overall, our findings shed light on a promising intervention pathway for addressing alcohol-related liver diseases.
Our results revealed that EPP can reverse changes in gut microbiota caused by alcohol consumption. Specifically, we observed an increase in beneficial bacteria such as Muribaculaceae, Lactobacillus, and Bacteroides, while harmful bacteria like Escherichia_Shigella and Enterococcus decreased. This shift in gut flora is critical as it can enhance gut barrier integrity through the production of short-chain fatty acids, particularly n-butyric acid.
Furthermore, EPP improved liver metabolic profiles, with highlighted metabolites and metabolic pathways related to nitrogen metabolism coming to the forefront. Notably, we found significant connections between the gut microbes and liver metabolites, showcasing that EPP helps to alleviate liver damage by working through the gut-liver axis. Overall, our findings shed light on a promising intervention pathway for addressing alcohol-related liver diseases.
Read More
9
Echinacea's role in liver protection
We explored the protective effects of Echinacea purpurea polysaccharides, particularly one fraction known as EPP80, on liver health in the context of alcoholic liver disease (ALD). The study identified EPP80, with a molecular weight of 11.82 kDa, as the most effective fraction, showcasing strong antioxidant properties in laboratory tests. It captured our interest how EPP80 could work against dangerous free radicals, potentially lowering the risk of liver damage.
In our investigation, we found that EPP80 not only enhanced the body’s natural defenses by increasing antioxidant enzyme levels but also reduced harmful inflammatory markers in both the bloodstream and liver of mice subjected to alcohol. Additionally, EPP80 showed promising results in improving intestinal barrier function by upregulating specific proteins essential for gut integrity.
Furthermore, EPP80 appeared to mitigate oxidative damage to the liver by promoting key protective pathways, indicating that it works on multiple fronts to combat the adverse effects of alcohol. These findings suggest a significant potential for incorporating Echinacea into strategies for preventing and managing ALD, which could be beneficial for those at risk.
In our investigation, we found that EPP80 not only enhanced the body’s natural defenses by increasing antioxidant enzyme levels but also reduced harmful inflammatory markers in both the bloodstream and liver of mice subjected to alcohol. Additionally, EPP80 showed promising results in improving intestinal barrier function by upregulating specific proteins essential for gut integrity.
Furthermore, EPP80 appeared to mitigate oxidative damage to the liver by promoting key protective pathways, indicating that it works on multiple fronts to combat the adverse effects of alcohol. These findings suggest a significant potential for incorporating Echinacea into strategies for preventing and managing ALD, which could be beneficial for those at risk.
Read More
9
We explored the potential benefits of chicoric acid, a compound derived from Echinacea, in addressing liver damage caused by acute alcohol consumption. Our research involved female mice who received chicoric acid for four days before being given a high dose of alcohol. This approach allowed us to understand the protective effects of this natural compound on the liver in such scenarios.
The results were promising. Acute alcohol intake typically leads to an increase in fat accumulation in the liver and activates damaging pathways associated with inflammation and oxidative stress. However, our study found that pre-treating the mice with chicoric acid reduced these harmful effects. Specifically, we observed a decrease in markers related to liver injury, including a reduction in a protein called inducible nitric oxide synthase (iNOS), which is often elevated during liver inflammation.
Furthermore, in lab tests with immune cells, chicoric acid significantly lowered the expression of inflammatory markers. This suggests that it could play a role not just as an antioxidant, but also in modulating immune responses within the liver. Overall, our findings indicate that chicoric acid has the potential to reduce acute alcohol-induced liver damage through its ability to interfere with damaging cellular pathways.
The results were promising. Acute alcohol intake typically leads to an increase in fat accumulation in the liver and activates damaging pathways associated with inflammation and oxidative stress. However, our study found that pre-treating the mice with chicoric acid reduced these harmful effects. Specifically, we observed a decrease in markers related to liver injury, including a reduction in a protein called inducible nitric oxide synthase (iNOS), which is often elevated during liver inflammation.
Furthermore, in lab tests with immune cells, chicoric acid significantly lowered the expression of inflammatory markers. This suggests that it could play a role not just as an antioxidant, but also in modulating immune responses within the liver. Overall, our findings indicate that chicoric acid has the potential to reduce acute alcohol-induced liver damage through its ability to interfere with damaging cellular pathways.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Boosts immunity
1 people found this helpful
Echinacea has significantly bolstered my immunity and cleansed my lymphatic system and blood. It combats viruses, bacteria, and fungi, effectively activating my body's defences against illness. I've noticed positive effects on my bronchial and pulmonary health, and it helps with otitis and sinusitis. I take one capsule daily.
Read More
7.5
Supports liver health
This dietary supplement excellently promotes liver health and improves skin. It features a natural and safe formula, offering cumulative benefits without concerns. With easy-to-use packaging, it is suitable for all ages.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Jing G, Xu W, Ma W, Yu Q, Zhu H, et al. Echinacea purpurea polysaccharide intervene in hepatocellular carcinoma via modulation of gut microbiota to inhibit TLR4/NF-κB pathway. Int J Biol Macromol. 2024;261:129917. doi:10.1016/j.ijbiomac.2024.129917
- Yu T, He Y, Chen H, Lu X, Ni H, et al. Polysaccharide from Echinacea purpurea plant ameliorates oxidative stress-induced liver injury by promoting Parkin-dependent autophagy. Phytomedicine. 2022;104:154311. doi:10.1016/j.phymed.2022.154311
- Jiang W, Zhu H, Liu C, Hu B, Guo Y, et al. In-depth investigation of the mechanisms of Echinacea purpurea polysaccharide mitigating alcoholic liver injury in mice via gut microbiota informatics and liver metabolomics. Int J Biol Macromol. 2022;209:1327. doi:10.1016/j.ijbiomac.2022.04.131
- Xu W, Hu B, Cheng Y, Guo Y, Yao W, et al. Echinacea purpurea suppresses the cell survival and metastasis of hepatocellular carcinoma through regulating the PI3K/Akt pathway. Int J Biochem Cell Biol. 2022;142:106115. doi:10.1016/j.biocel.2021.106115
- Jiang W, Zhu H, Xu W, Liu C, Hu B, et al. Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver-related pathways. Int J Biol Macromol. 2021;187:143. doi:10.1016/j.ijbiomac.2021.07.095
- Xu W, Zhu H, Hu B, Cheng Y, Guo Y, et al. Echinacea in hepatopathy: A review of its phytochemistry, pharmacology, and safety. Phytomedicine. 2021;87:153572. doi:10.1016/j.phymed.2021.153572
- Guo R, Zhao B, Wang Y, Wu D, Wang Y, et al. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. J Agric Food Chem. 2018;66:9667. doi:10.1021/acs.jafc.8b02147
- Shawky H, Maghraby AS, Solliman Mel-D, El-Mokadem MT, Sherif MM, et al. Expression, immunogenicity and diagnostic value of envelope proteins from an Egyptian hepatitis C virus isolate. Arch Virol. 2015;160:945. doi:10.1007/s00705-015-2334-1
- Landmann M, Kanuri G, Spruss A, Stahl C, Bergheim I. Oral intake of chicoric acid reduces acute alcohol-induced hepatic steatosis in mice. Nutrition. 2014;30:882. doi:10.1016/j.nut.2013.11.015
- Hou CC, Huang CC, Shyur LF. Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute hepatic injury through JNK pathway-mediated HO-1 expression. J Agric Food Chem. 2011;59:11966. doi:10.1021/jf202958r
- Ali EH. Protective effects of Echinacea on cyproterone acetate induced liver damage in male rats. Pak J Biol Sci. 2008;11:2464.
- Rusu MA, Tamas M, Puica C, Roman I, Sabadas M. The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver. Phytother Res. 2005;19:744.
- Marchenko MM, Kopyl'chuk HP, Hrygor'ieva OV. [Activity of cytoplasmic proteinases from rat liver in Heren's carcinoma during tumor growth and treatment with medicinal herbs]. Ukr Biokhim Zh (1999). 2000;72:91.
- Lersch C, Zeuner M, Bauer A, Siebenrock K, Hart R, et al. Stimulation of the immune response in outpatients with hepatocellular carcinomas by low doses of cyclophosphamide (LDCY), echinacea purpurea extracts (Echinacin) and thymostimulin. Arch Geschwulstforsch. 1990;60:379.
